Pyglet uses OpenGL. It makes blitting a 2D image as simple as
image.blit(x,y)The API is exceptionally clean, IMO, and is accompanied by a programming guide and an API reference.
It also allows you to code for multi-head setups, and provides positional audio via OpenAL. Awesome! And best of all... there is no building required! It's 100% Pure Python.
Pyglet is still in alpha phase, so don't expect everything to work perfectly. Having said that... it works well enough for me. I'm converted.